(7R,14R)-11-Chloro-1-(difluoromethoxy)-10-fluoro-6,7-dihydro-7,14-methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)--one

(7R,14R)-11-chloro-1-(difluoromethoxy)-9-fluoro-6,7-dihydro-7,14-Methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)--one

(7R,14R)-11-Chloro-1-(difluoromethoxy)-6,7-dihydro-7,14-methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)--one

(7R,14R)-1-(difluoromethoxy)-11-(2-((1s,3S)-3-(fluoromethyl)-1-hydroxy-3-methylcyclobutyl)pyrimidin-5-yl)-6-((1-(fluoromethyl)cyclopropyl)methyl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

(7R,14R)-11-[6-[trans-1-amino-3-hydroxy-3-(trifluoromethyl)cyclobutyl]-5-fluoropyridin-3-yl]-1-(difluoromethoxy)-6,7-dihydro-6-methyl-7,14-Methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)--one

(7R,14R)-11-[6-[cis-1-amino-3-hydroxy-3-(trifluoromethyl)cyclobutyl]-5-fluoropyridin-3-yl]-1-(difluoromethoxy)-6,7-dihydro-6-methyl-7,14-Methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)--one

(1R,3r)-3-(5-((7R,14R)-1-(difluoromethoxy)-6-ethyl-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-11-yl)pyrimidin-2-yl)-1-(fluoromethyl)-3-hydroxycyclobutanecarbonitrile

(7R,14R)-11-(2-(1-aminocyclobutyl)pyrimidin-5-yl)-1-(difluoromethoxy)-6-((1-(fluoromethyl)cyclopropyl)methyl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

(7R,14R)-11-[3-amino-2,3-dihydro-3-(1-propyn-1-yl)-furo[3,2-b]pyridin-6-yl]-1-(cyclopropylmethoxy)-6,7-dihydro-6-methyl-7,14-Methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)--one

(7R,14R)-11-[2-chloro-4-(dimethylphosphinyl)phenyl]-1-(difluoromethoxy)-6,7-dihydro-6-methyl-7,14-Methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)--one

(7R,14R)-11-[6-(diethylphosphinyl)-pyridin-3-yl]-1-(difluoromethoxy)-6,7-dihydro-7,14-Methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)--one

(7R,14R)-11-[4-(diethylphosphinyl)-3-fluorophenyl]-1-(difluoromethoxy)-6,7-dihydro-7,14-Methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)--one

(7R,14R)-11-[4-(diethylphosphinyl)-2-fluorophenyl]-1-(difluoromethoxy)-6,7-dihydro-7,14-Methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)--one

(7R,14R)-11-(2-((1r,3R)-3-cyano-3-(fluoromethyl)-1-hydroxycyclobutyl)pyrimidin-5-yl)-1-(difluoromethoxy)-6-((1-fluorocyclopropyl)methyl)-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocine-4-carbonitrile

(1S,3s)-3-(5-((7R,14R)-1-(difluoromethoxy)-6-((1-(fluoromethyl)cyclopropyl)methyl)-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-11-yl)pyrimidin-2-yl)-3-hydroxy-1-methylcyclobutanecarbonitrile

(7R,14R)-11-[6-[cis-1-amino-3-hydroxy-3-(trifluoromethyl)cyclobutyl]-5-fluoropyridin-3-yl]-1-(difluoromethoxy)-6,7-dihydro-6-methyl-7,14-methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)--one formate

(7R,14R)-11-[6-[cis-1-amino-3-hydroxy-3-(trifluoromethyl)cyclobutyl]-5-fluoropyridin-3-yl]-1-(difluoromethoxy)-6,7-dihydro-7,14-Methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)--one HCl

(1R,3r)-3-(5-((7R,14R)-1-(difluoromethoxy)-6-((1-(fluoromethyl)cyclopropyl)methyl)-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-11-yl)pyrimidin-2-yl)-1-(fluoromethyl)-3-hydroxycyclobutanecarbonitrile

(7R,14R)-11-[4-amino-4-(fluoromethyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-7-yl]-1-[(1-fluoro-cyclopropyl)methoxy]-6,7-dihydro-6-methyl-7,14-Methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)--one

(7R,14R)-11-[6-[cis-1-amino-3-hydroxy-3-(trifluoromethyl)cyclobutyl]-5-fluoropyridin-3-yl]-1-(difluoromethoxy)-6,7-dihydro-7,14-Methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)--one